Oxford College starts professional trial of anti-CD47 antibody in the therapy of severe myeloid leukemia

Weissman, in addition to Affiliate Teacher of Medication Ravi Majeti, MD, PhD and also their associates at Stanford, then established an antibody that blocked the CD47 signal and also provided it to mice that had actually been dosed with human leukemia cells. Untreated, the leukemia cells would increase and eliminate the mouse. During the first such experiment, nonetheless, the antibody enabled the...

Precursor cells discovered that could help regrow heart arteries

Scientists previously showed that portions of the coronary artery develop from cells on the surface of the heart called epicardial cells. However, the direct progenitors to coronary artery smooth muscle cells, the important component that encases the artery and gives it strength, were not identified. Scientists have known very little about how collateral blood vessels form to reroute blood flow around...

Leukemia mutations alter DNA structure to preserve stem cell traits

Ravi Majeti, MD, PhD Researchers at the Stanford Institute discovered that a fundamental mutation in some cancers preserves certain stem cell qualities that should be lost, and also stops cancer cells from becoming more specialized. The finding brings scientists slightly closer to understanding how cancers develop, and perhaps how to treat them, the researchers say. The research was published Oct...

Sleep deprivation affects stem cells, reducing transplant efficiency

Rolls and her colleagues compared the ability of fluorescently labeled stem cells from sleepy and from rested mice to migrate properly from the recipients’ blood into the bone marrow. After 12 hours, 3.3 percent of stem cells from spritely mice were found in the bone marrow, versus only 1.7 percent of stem cells from sleepy mice. We go to all this trouble to find a matching donor, but this research...

Healing broken bones requires specialized stem cells

From left: Charles Chan, Owen Marecic and Michael Longaker By Christopher Vaughan Stanford stem cell researcher Michael Longaker, MD and his colleagues announced that they have discovered the stem cell responsible for healing bone fractures in mice. The identification of the bone repair stem cell in mice and eventually in humans could lead to improved healing after bones are broken. The research...

Viral proteins may regulate human embryonic development

“Does the virus selfishly benefit by switching itself on in these early embryonic cells?” said Grow. “Or is the embryo instead commandeering the viral proteins to protect itself? Can they both benefit? That’s possible, but we don’t really know.” “There is a long-standing debate within the field of genome evolution,” Grow said. “Why retain so much seemingly useless and repetitive DNA...

Mind lump development stimulated by nerve task in the cortex, research locates

The lead writers of the study are graduate student Humsa Venkatesh, MD/PhD pupil Tessa Johung and also postdoctoral historian Viola Caretti, MD, POSTGRADUATE DEGREE. To carry out the research study, Monje’s team utilized optogenetics, a Stanford-developed strategy that makes use of genetic control to insert light-sensitive proteins right into specific neurons, enabling the neurons to be triggered...

5 Concerns: Maria Grazia Roncarolo on advances in gene therapy

Roncarolo: I would certainly make a difference. The ladder of translational study contains different actions, from the action of identifying the genetics that is defective, when it come to genetic conditions, to the action in recognizing the mechanism that induced the condition and also to the step of targeting the illness for gene treatment. There are many various other tests in the Usa and also in...

Girl’s massive airway tumor treated through new therapy

Massive spread “It was becoming tangled into every structure in her neck and crawling down into her chest,” said Mai Thy Truong, MD, a pediatric otolaryngologist now with the hospital’s vascular malformations clinic, which treats children with hemangiomas and other vascular tumors. At the time of Isabella’s treatment, Truong was completing an otolaryngology fellowship under Chang’s tutelage...

New way to sort cells without limitations of traditional methods

Can you take a tissue, blend it up, look at the contents and tell what kinds of cells they came from? In addition to avoiding the problems inherent in breaking up tissues into single cells, researchers using this method won’t need fluorescently labeled antibodies for the cell surface markers they are looking for, he said. “There are early hints that it is very important to know about the presence...